Overview
The Discovery Science sub-theme aims to discover new biomarkers of cardiovascular disease through both basic and advanced methodologies such as proteomics and metabolomics. By establishing collaborations, we aim to investigate these biomarkers on a mechanistic level in vitro and in experimental settings, ultimately providing accurate targets for cardiovascular disease intervention.
Sub-theme Leader: Prof Wayne Smith
- Urinary Metabolites and Their Link with Premature Arterial Stiffness in Black Boys: The ASOS Study
- Central systolic pressure and a nonessential amino acid metabolomics profile: the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension
- Left ventricular mass and urinary metabolomics in young black and white adults: The African-PREDICT study
- Urinary metabolomics profiling by cardiovascular risk factors in young adults: the African Prospective study on Early Detection and Identification of Cardiovascular disease and Hypertension study
- Identifying a metabolomics profile associated with masked hypertension in two independent cohorts: Data from the African-PREDICT and SABPA studies
- A urinary peptidomics approach for early stages of cardiovascular disease risk: The African-PREDICT study
- Urinary metabolomics, dietary salt intake and blood pressure: the African-PREDICT study
- Identifying a urinary peptidomics profile for hypertension in young adults: The African-PREDICT study
- Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study
- Using urinary metabolomics to identify metabolic pathways linked to cardiac structural alterations in young adults: The African-PREDICT study
- Early vascular ageing phenotypes and urinary targeted metabolomics in children and young adults: the ExAMIN Youth SA and African-PREDICT studies
- Urinary Peptidomics and Pulse Wave Velocity: The African-PREDICT Study
In collaboration with Pharmacology